“Today, if a child with aplastic anemia has a matched related donor, we recommend proceeding with bone marrow transplant,” said Dr. Gupta. http://youtube.com/watch?feature=kp&v=Pf7JuJcVzQU“If no such optimum donor exists, as is true for almost 80 percent of children, immunosuppressive therapy (IST) is the standard of care, despite high rates of disease recurrence following treatment conclusion. As the outcomes of matched unrelated donor transplant options have improved, we wanted to know if patients with aplastic anemia were also experiencing better long term outcomes compared to immunosuppressive therapy, which is known to have high failure rates. Incidence of complications with bone marrow transplant also increases with delay in transplant.” Through extensive data analysis, the research team found that outcomes were comparable between matched related bone marrow transplant and matched unrelated donor transplants. Interestingly, common post-transplant complications such as graft versus host disease or graft failure were actually lower for patients who underwent a transplant from a matched unrelated donor. “Children particularly tolerate transplants better than adults,” added Dr. Gupta. “It is reasonable to recommend matched unrelated donor transplants in place of IST if a suitable donor is available.” http://www.blueridgefilmfest.com/luisramirezonline/2016/10/07/a-helpful-breakdown-of-central-criteria-of-course-for-selection-interviewDr. Gupta’s presentation appears as part of the ASH Poster Session (Abstract 2395) entitled Outcomes Research-Non-Malignant Conditions.
For the original version including any supplementary images or video, visit https://www.eurekalert.org/pub_releases/2016-12/uhcm-urb120116.php
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